Konferenzbeitrag
Probabilistic methods for predicting protein functions in protein-protein interaction networks
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Datum
2004
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Gesellschaft für Informatik e.V.
Zusammenfassung
We discuss probabilistic methods for predicting protein functions from protein-protein interaction networks. Previous work based on Markov Randon Fields is extended and compared to a general machine-learning theoretic approach. Using actual protein interaction networks for yeast from the MIPS database and GO-SLIM function assignments, we compare the predictions of the different probabilistic methods and of a standard support vector machine. It turns out that, with the currently available networks, the simple methods based on counting frequencies perform as well as the more sophisticated approaches.