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Planning isotopomer measurements for estimation of metabolic fluxes

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dc.contributor.authorRantanen, Ari
dc.contributor.authorMielikäinen, Taneli
dc.contributor.authorRousu, Juho
dc.contributor.authorUkkonen, Esko
dc.contributor.editorTorda, Andrew
dc.contributor.editorKurtz, Stefan
dc.contributor.editorRarey, Matthias
dc.date.accessioned2019-08-27T08:22:36Z
dc.date.available2019-08-27T08:22:36Z
dc.date.issued2005
dc.description.abstractFlux estimation by using isotopomer information of metabolites is currently the only method that can give quantitative estimates of the activity of metabolic pathways. However, the measurement of isotopomer distributions of intermediate metabolites is costly and tedious with current technologies. In this paper we study the question of finding the smallest subset of metabolites to measure that ensure an adequate level of the isotopomer information. We study the computational complexity of this optimization problem in the case of the so-called positional enrichment data, give exact and fast heuristic solutions and evaluate empirically the efficacy of the proposed methods.en
dc.identifier.isbn3-88579-400-4
dc.identifier.pissn1617-5468
dc.identifier.urihttps://dl.gi.de/handle/20.500.12116/24933
dc.language.isoen
dc.publisherGesellschaft für Informatik e.V.
dc.relation.ispartofGerman Conference on Bioinformatics 2005 (GCB 2005)
dc.relation.ispartofseriesLecture Notes in Informatics (LNI) - Proceedings, Volume P-71
dc.titlePlanning isotopomer measurements for estimation of metabolic fluxesen
dc.typeText/Conference Paper
gi.citation.endPage191
gi.citation.publisherPlaceBonn
gi.citation.startPage177
gi.conference.date5.-7. Oktober 2005
gi.conference.locationHamburg
gi.conference.sessiontitleRegular Research Papers

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P071 - GCB 2005 - German Conference on Bioinformatics