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P235 - GCB 2014 - German Conference on Bioinformatics 2014

https://dl.gi.de/handle/20.500.12116/21227
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Auflistung P235 - GCB 2014 - German Conference on Bioinformatics 2014 nach Autor:in "Backofen, Rolf"

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  • Konferenzbeitrag
    Blockclust: efficient clustering and classification of non-coding rnas from short Read RNA-seq profiles
    (German conference on bioinformatics 2014, 2014) Videm, Pavankumar; Rose, Dominic; Costa, Fabrizio; Backofen, Rolf
    Sequence and secondary structure analysis can be used to assign putative functions to non-coding RNAs. However sequence information is changed by post-transcriptional modifications and secondary structure is only a proxy for the true 3D conformation of the RNA polymer. In order to tackle these issues we can extract a different type of description using the pattern of processing that can be observed through the traces left in small RNA-seq reads data. To obtain an efficient and scalable procedure, we propose to encode expression profiles in discrete structures, and process them using fast graph-kernel techniques.