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Auflistung nach Autor:in "Cijvat, Robin"

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  • Zeitschriftenartikel
    Genome sequence analysis with MonetDB
    (Datenbank-Spektrum: Vol. 15, No. 3, 2015) Cijvat, Robin; Manegold, Stefan; Kersten, Martin; Klau, Gunnar W.; Schönhuth, Alexander; Marschall, Tobias; Zhang, Ying
    Next-generation sequencing (NGS) technology has led the life sciences into the big data era. Today, sequencing genomes takes little time and cost, but yields terabytes of data to be stored and analyzed. Biologists are often exposed to excessively time consuming and error-prone data management and analysis hurdles. In this paper, we propose a database management system (DBMS) based approach to accelerate and substantially simplify genome sequence analysis. We have extended MonetDB, an open-source column-based DBMS, with a BAM module, which enables easy, flexible, and rapid management and analysis of sequence alignment data stored as Sequence Alignment/Map (SAM/BAM) files. We describe the main features of MonetDB/BAM using a case study on Ebola virusgenomes.
  • Konferenzbeitrag
    Genome sequence analysis with monetdb: a case study on ebola virus diversity
    (Datenbanksysteme für Business, Technologie und Web (BTW 2015) - Workshopband, 2015) Cijvat, Robin; Manegold, Stefan; Kersten, Martin; Klau, Gunnar W.; Schönhuth, Alexander; Marschall, Tobias; Zhang, Ying
    Next-generation sequencing (NGS) technology has led the life sciences into the big data era. Today, sequencing genomes takes little time and cost, but results in terabytes of data to be stored and analysed. Biologists are often exposed to excessively time consuming and error-prone data management and analysis hurdles. In this paper, we propose a database management system (DBMS) based approach to accelerate and substantially simplify genome sequence analysis. We have extended MonetDB, an open-source column-based DBMS, with a BAM module, which enables easy, flexible, and rapid management and analysis of sequence alignment data stored as Sequence Alignment/Map (SAM/BAM) files. We describe the main features of MonetDB/BAM using a case study on Ebola virus genomes.