Auflistung nach Autor:in "Gorodkin, Jan"
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- KonferenzbeitragMaximum likelihood estimation of weight matrices for targeted homology search(German conference on bioinformatics 2009, 2009) Menzel, Peter; Gorodkin, Jan; Stadler, Peter F.Genome annotation relies to a large extent on the recognition of homologs to already known genes. The starting point for such protocols is a collection of known sequences from one or more species, from which a model is constructed – either automatically or manually – that encodes the defining features of a single gene or a gene family. The quality of these models eventually determines the success rate of the homology search. We propose here a novel approach to model construction that not only captures the characteristic motifs of a gene, but are also adjusts the search pattern by including phylogenetic information. Computational tests demonstrate that this can lead to a substantial improvement of homology search models.