With the advent of tablet computers, touch screens, gesture-based interaction and speech recognition, sophisticated applications with Natural User Interfaces (NUIs) become state of the art. NUIs have the potential to support people with disabilities, e.g., in their daily activities or in acquiring specific skills. Yet, one main challenge is that this user group has diverse abilities and handicaps so that an interaction design must be highly configurable to make NUIs beneficial. The introduction of adaptivity might be promising in order to overcome configuration complexity and effort. This paper presents an approach to adaptive user interfaces on tablets to support people with disabilities.