Industrie 4.0, the transition from static, centrally controlled production to dynamic, decentralized manufacturing, is aiming to increase product quality, customization and efficiency. Autonomous production systems and flexible inter-organizational cooperation are key challenges. Blockchain seems to be a natural fit to cope with these challenges. This article derives major challenges of I4.0 and compares them with benefits of blockchain technology. Use cases demonstrate where challenges and benefits match. Also, well known blockchain issues and possible solutions are addressed.