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dc.contributor.authorFutschik, Matthias E.
dc.contributor.authorChaurasia, Gautam
dc.contributor.authorWanker, Erich
dc.contributor.authorHerzel, Hanspeter
dc.contributor.editorHuson, Daniel
dc.contributor.editorKohlbacher, Oliver
dc.contributor.editorLupas, Andrei
dc.contributor.editorNieselt, Kay
dc.contributor.editorZell, Andreas
dc.date.accessioned2019-08-12T13:06:19Z
dc.date.available2019-08-12T13:06:19Z
dc.date.issued2006
dc.identifier.isbn978-3-88579-177-5
dc.identifier.issn1617-5468
dc.identifier.urihttp://dl.gi.de/handle/20.500.12116/24212
dc.description.abstractLarge-scale mappings of protein-protein interactions have started to give us new views of the complex molecular mechanisms inside a cell. After initial projects to systematically map protein interactions in model organisms such as yeast, worm and fly, researchers have begun to focus on the mapping of the human interactome. To tackle this enormous challenge, different approaches have been proposed and pursued. While several large-scale human protein interaction maps have recently been published, their quality remains to be critically assessed. We present here a first comparative analysis of eight currently available large-scale maps with a total of over 10000 unique proteins and 57000 interactions included. They are based either on literature search, orthology or by yeast-two-hybrid assays. Comparison reveals only a small, but statistically significant overlap. More importantly, our analysis gives clear indications that all interaction maps suffer under selection and detection biases. These results have to be taken into account for future assembly of the human interactome.en
dc.language.isoen
dc.publisherGesellschaft für Informatik e.V.
dc.relation.ispartofGerman Conference on Bioinformatics
dc.relation.ispartofseriesLecture Notes in Informatics (LNI) - Proceedings, Volume P-83
dc.titleComparison of human protein-protein interaction mapsen
dc.typeText/Conference Paper
dc.pubPlaceBonn
mci.reference.pages21-32
mci.conference.sessiontitleRegular Research Papers
mci.conference.locationTübingen
mci.conference.dateSeptember 19-22, 2006


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