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A model of specificity and selectivity of mammalian cytochrome P450 monooxygenases

Author:
Seifert, Alexander [DBLP] ;
Krahn, Michael [DBLP] ;
Tatzel, Stephan [DBLP] ;
Schmid, Rolf D. [DBLP] ;
Pleiss, Jürgen [DBLP]
Abstract
Multiple molecular dynamics simulations and a systematic analysis of sequence and structure of mammalian cytochrome P450 monooxygenases were performed to investigate the structural basis of their specificity and selectivity. While the substrate binding cavity is mobile, the protein core and the access funnel to the heme are rigid. High mobility of the substrate binding pocket is consistent with the broad substrate profile observed for these enzymes, while the rigid core mediates regioselectivity by controlling substrate access to the heme. For enzymes with narrow heme access funnels, only highly accessible positions in substrates are accepted, while for enzymes with a more exposed heme regioselectivity is driven by chemical reactivity of the substrate.
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Seifert, A., Krahn, M., Tatzel, S., Schmid, R. D. & Pleiss, J., (2005). A model of specificity and selectivity of mammalian cytochrome P450 monooxygenases. In: Torda, A., Kurtz, S. & Rarey, M. (Hrsg.), German Conference on Bioinformatics 2005 (GCB 2005). Bonn: Gesellschaft für Informatik e.V.. (S. 147-157).
@inproceedings{mci/Seifert2005,
author = {Seifert, Alexander AND Krahn, Michael AND Tatzel, Stephan AND Schmid, Rolf D. AND Pleiss, Jürgen},
title = {A model of specificity and selectivity of mammalian cytochrome P450 monooxygenases},
booktitle = {German Conference on Bioinformatics 2005 (GCB 2005)},
year = {2005},
editor = {Torda, Andrew AND Kurtz, Stefan AND Rarey, Matthias} ,
pages = { 147-157 },
publisher = {Gesellschaft für Informatik e.V.},
address = {Bonn}
}
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More Info

ISBN: 3-88579-400-4
ISSN: 1617-5468
xmlui.MetaDataDisplay.field.date: 2005
Language: en (en)
Content Type: Text/Conference Paper
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Gesellschaft für Informatik e.V. (GI), Kontakt: Geschäftsstelle der GI
Diese Digital Library basiert auf DSpace.