Show simple item record

dc.contributor.authorMückstein, Ulrike
dc.contributor.authorTafer, Hakim
dc.contributor.authorHackermüller, Jörg
dc.contributor.authorBernhart, Stephan H.
dc.contributor.authorStadler, Peter F.
dc.contributor.authorHofacker, Ivo L.
dc.contributor.editorTorda, Andrew
dc.contributor.editorKurtz, Stefan
dc.contributor.editorRarey, Matthias
dc.date.accessioned2019-08-27T08:22:36Z
dc.date.available2019-08-27T08:22:36Z
dc.date.issued2005
dc.identifier.isbn3-88579-400-4
dc.identifier.issn1617-5468
dc.identifier.urihttp://dl.gi.de/handle/20.500.12116/24932
dc.description.abstractWe present an extension of the standard partition function approach to RNA secondary structures that computes the probabilities Pu[i, j] that a sequence interval [i, j] is unpaired. Comparison with experimental data shows that Pu[i, j] can be applied as a significant determinant of local target site accessibility for RNA interference (RNAi). Furthermore, these quantities can be used to rigorously determine binding free energies of short oligomers to large mRNA targets. The resource consumption is comparable to a single partition function computation for the large target molecule. We can show that RNAi efficiency correlates well with the binding probabilities of siRNAs to their respective mRNA target.en
dc.language.isoen
dc.publisherGesellschaft für Informatik e.V.
dc.relation.ispartofGerman Conference on Bioinformatics 2005 (GCB 2005)
dc.relation.ispartofseriesLecture Notes in Informatics (LNI) - Proceedings, Volume P-71
dc.subjectRNA secondary structure
dc.subjectRNA hybridization
dc.subjectdynamic programming
dc.titleThermodynamics of RNA-RNA bindingen
dc.typeText/Conference Paper
dc.pubPlaceBonn
mci.reference.pages3-13
mci.conference.sessiontitleRegular Research Papers
mci.conference.locationHamburg
mci.conference.date5.-7. Oktober 2005


Files in this item

Thumbnail

Show simple item record