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dc.contributor.authorLingner, Thomas
dc.contributor.authorMeinicke, Peter
dc.contributor.editorGiegerich, Robert
dc.contributor.editorHofestädt, Ralf
dc.contributor.editorNattkemper, Tim W.
dc.date.accessioned2017-07-26T14:12:12Z
dc.date.available2017-07-26T14:12:12Z
dc.date.issued2014
dc.identifier.isbn978-3-88579-629-9
dc.identifier.issn1617-5468
dc.description.abstractIn metagenomics, the discovery of functional novelty has always been pursued in a gene-centered manner. In that way, sequence-based analysis has been restricted to particular features and to a sufficient length of the sequences. We propose a statistical approach that is independent from the identification of single sequences but rather yields an overall characterization of a metagenome. Our method is based on the analysis of significant differences between the functional profile of a metagenome and its reconstruction from a combination of genomic profiles using the Taxy-Pro mixture model. Here, protein families with a large proportion of domain hits that cannot be explained by the model are interesting candidates for the exploration of metagenomic novelty. The results of three case studies indicate that our method is able to characterize metagenomic novelty in terms of the protein families that significantly contribute to unexplained domain counts. We found a good correspondence between our predictions and the discoveries in the original studies as well as specific indicators of functional novelty that have not yet been described.en
dc.language.isoen
dc.publisherGesellschaft für Informatik e.V.
dc.relation.ispartofGerman conference on bioinformatics 2014
dc.relation.ispartofseriesLecture Notes in Informatics (LNI) - Proceedings, Volume P-235
dc.titleCharacterizing metagenomic novelty with unexplained protein domain hitsen
dc.typeText/Conference Paper
dc.pubPlaceBonn
mci.reference.pages69-78
mci.conference.locationBielefeld
mci.conference.date28. September - 1. October 2014


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