Efficient similarity retrieval of protein binding sites based on histogram comparison
ISSN der Zeitschrift
German Conference on Bioinformatics 2010
Regular Research Papers
Gesellschaft für Informatik e.V.
We propose a method for comparing protein structures or, more specifically, protein binding sites using a histogram-based representation that captures important geometrical and physico-chemical properties. In comparison to hitherto existing approaches in structural bioinformatics, especially methods from graph theory and computational geometry, our approach is computationally much more efficient. Moreover, despite its simplicity, it appears to capture and recover functional similarities surprisingly well.