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Towards accurate transcription start site prediction: a modelling approach

dc.contributor.authorDjordjevic, Marko
dc.contributor.editorGiegerich, Robert
dc.contributor.editorHofestädt, Ralf
dc.contributor.editorNattkemper, Tim W.
dc.date.accessioned2017-07-26T14:12:11Z
dc.date.available2017-07-26T14:12:11Z
dc.date.issued2014
dc.description.abstractPromoter prediction in bacteria is a classical bioinformatics problem, where available methods for regulatory element detection exhibit a very high number of false positives. We here argue that accurate transcription start site (TSS) prediction is a complex problem, where available methods for sequence motif discovery are not in itself well adopted for solving the problem. We here instead propose that the problem requires integration of quantitative understanding of transcription initiation with careful description of promoter sequence specificity. We review evidence for this viewpoint based on our recent work, and discuss a current progress on accurate TSS detection on the example of sigma70 transcription start sites in E. coli.en
dc.identifier.isbn978-3-88579-629-9
dc.identifier.pissn1617-5468
dc.language.isoen
dc.publisherGesellschaft für Informatik e.V.
dc.relation.ispartofGerman conference on bioinformatics 2014
dc.relation.ispartofseriesLecture Notes in Informatics (LNI) - Proceedings, Volume P-235
dc.titleTowards accurate transcription start site prediction: a modelling approachen
dc.typeText/Conference Paper
gi.citation.endPage105
gi.citation.publisherPlaceBonn
gi.citation.startPage99
gi.conference.date28. September - 1. October 2014
gi.conference.locationBielefeld

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