Menzel, PeterStadler, Peter F.Mosig, AxelFalter, ClaudiaSchliep, AlexanderSelbig, JoachimVingron, MartinWalther, Dirk2019-05-152019-05-152007978-3-88579-209-3https://dl.gi.de/handle/20.500.12116/22375We present a combinatorial method for discovering cis-regulatory modules in promoter sequences. Our approach combines “sliding window” approaches with a scoring function based on the so-called Tanimoto score. This allows to identify sets of binding sites that tend to occur preferentially in the vicinity of each other in a given set of promoter sequences belonging to co-expressed or orthologous genes. We bench- mark our method on a data set derived from muscle-specific genes, demonstrating that our approach is capable of identifying modules that were identified as functional in previous studies.enText/Conference Paper1617-5468