Luz, HannesVingron, MartinTorda, AndrewKurtz, StefanRarey, Matthias2019-08-272019-08-2720053-88579-400-4https://dl.gi.de/handle/20.500.12116/24927Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic protein families in a maximum likelihood framework. We find that the evolution of indispensable proteins is constrained by selection and that protein secretion is coupled to an increased evolutionary rate.enText/Conference Paper1617-5468