Dorok, SebastianBreß, SebastianTeubner, JensLäpple, HorstfriedSaake, GunterMarkl, VolkerMitschang, BernhardNicklas, DanielaLeymann, FrankSchöning, HaraldHerschel, MelanieTeubner, JensHärder, TheoKopp, OliverWieland, Matthias2017-06-202017-06-202017978-3-88579-659-6Genome-analysis enables researchers to detect mutations within genomes and deduce their consequences. Researchers need reliable analysis platforms to ensure reproducible and comprehensive analysis results. Database systems provide vital support to implement the required sustainable procedures. Nevertheless, they are not used throughout the complete genome-analysis process, because (1) database systems su er from high storage overhead for genome data and (2) they introduce overhead during domain-specific analysis. To overcome these limitations, we integrate genome-specific compression into database systems using a specialized database schema. Thus, we can reduce the storage overhead to 30%. Moreover, we can exploit genome-data characteristics during query processing allowing us to analyze real-world data sets up to five times faster than specialized analysis tools and eight times faster than a straightforward database approach.enmain-memory database systemsgenome analysisvariant callingText/Conference Paper1617-5468