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Tanimoto’s Best Barbecue: Discovering Regulatory Modules using Tanimoto Scores

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2007

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Gesellschaft für Informatik e. V.

Zusammenfassung

We present a combinatorial method for discovering cis-regulatory modules in promoter sequences. Our approach combines “sliding window” approaches with a scoring function based on the so-called Tanimoto score. This allows to identify sets of binding sites that tend to occur preferentially in the vicinity of each other in a given set of promoter sequences belonging to co-expressed or orthologous genes. We bench- mark our method on a data set derived from muscle-specific genes, demonstrating that our approach is capable of identifying modules that were identified as functional in previous studies.

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Menzel, Peter; Stadler, Peter F.; Mosig, Axel (2007): Tanimoto’s Best Barbecue: Discovering Regulatory Modules using Tanimoto Scores. German conference on bioinformatics – GCB 2007. Bonn: Gesellschaft für Informatik e. V.. PISSN: 1617-5468. ISBN: 978-3-88579-209-3. pp. 68-77. Regular Research Papers. Potsdam. September 26-28, 2007, Potsdam,

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