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Family specific rates of protein evolution

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2005

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Gesellschaft für Informatik e.V.

Zusammenfassung

Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic protein families in a maximum likelihood framework. We find that the evolution of indispensable proteins is constrained by selection and that protein secretion is coupled to an increased evolutionary rate.

Beschreibung

Luz, Hannes; Vingron, Martin (2005): Family specific rates of protein evolution. German Conference on Bioinformatics 2005 (GCB 2005). Bonn: Gesellschaft für Informatik e.V.. PISSN: 1617-5468. ISBN: 3-88579-400-4. pp. 133-144. Regular Research Papers. Hamburg. 5.-7. Oktober 2005

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