A Propagation-based Algorithm for Inferring Gene-Disease Associations
| dc.contributor.author | Vanunu, Oron | |
| dc.contributor.author | Sharan, Roded | |
| dc.contributor.editor | Beyer, Andreas | |
| dc.contributor.editor | Schroeder, Michael | |
| dc.date.accessioned | 2019-04-03T12:07:34Z | |
| dc.date.available | 2019-04-03T12:07:34Z | |
| dc.date.issued | 2008 | |
| dc.description.abstract | A fundamental challenge in human health is the identification of disease- causing genes. Recently, several studies have tackled this challenge via a two-step approach: first, a linkage interval is inferred from population studies; second, a computational approach is used to prioritize genes within this interval. State-of-the-art methods for the latter task are based on the observation that genes causing the same or similar diseases tend to lie close to one another in a network of protein-protein or functional interactions. However, most of these approaches use only local network information in the inference process. Here we provide a global, network-based method for prioritizing disease genes. The method is based on formulating constraints on the prioritization function that relate to its smoothness over the network and usage of prior information. A propagation-based method is used to compute a function satisfying the constraints. We test our method on gene-disease association data in a cross-validation setting, and compare it to extant prioritization approaches. We show that our method provides the best overall performance, ranking the true causal gene first for 29% of the 1,369 diseases with a known gene in the OMIM knowledgebase. | en |
| dc.identifier.isbn | 978-3-88579-226-0 | |
| dc.identifier.uri | https://dl.gi.de/handle/20.500.12116/21221 | |
| dc.language.iso | en | |
| dc.publisher | Gesellschaft für Informatik e. V. | |
| dc.relation.ispartof | German Conference on Bioinformatics | |
| dc.relation.ispartofseries | Lecture Notes in Informatics (LNI) - Proceedings, Volume P-136 | |
| dc.title | A Propagation-based Algorithm for Inferring Gene-Disease Associations | en |
| dc.type | Text/Conference Paper | |
| gi.citation.endPage | 63 | |
| gi.citation.publisherPlace | Bonn | |
| gi.citation.startPage | 54 | |
| gi.conference.date | 09.-12.09.2008 | |
| gi.conference.location | Dresden | |
| gi.conference.sessiontitle | Regular Research Papers |
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